Yes I get this very frequently and reported it to RM months ago. There is no other App that should be making changes and I have experienced it after a Mac reboot with RW being the only App that I have started.
Also, frequently I will make changes to a project file and then Publish Locally and I don’t get any Save dialog box. Also I have Saved a project and if I then Close and Quit RW, on restarting RW, it auto opens the same Project and if I then Close it without making any changes, it will ask me to Save it first.
Using RW7.41 with Stacks 3.5 and no other Add-Ons & OSX 10.12.6 .