Is there a text-to-speech stack?

I’m trying to create something for a semi-blind individual

There never use to be one, until now

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Shouldn’t that be better solved by screen-reader software?

My mother is legally blind but she can see shapes and text if it is very large (~1" tall). She is also semi shut-in. She can get groceries delivered but may have trouble remembering what she needs. I want to develop a proof-of-concept where she can see the word, press the word and have an audible confirmation, then eventually select that item to the list. Is a screen reader stack better choice than text-to-speech for this idea?

Well, that would not be a screen reader Stack, but software on your computer or mobile phone narrating the screen content. E.g. http://www.apple.com/accessibility/ios/